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The PC native software I use, SAWStudio, has a "Live" mode where you can pass signal through it's processors in real time as if it was just another piece of hardware and toggle between any amount of plugin snapshot automations you wish. It's native plugins (which are generally much more cpu efficient than other protocols) are 100% fully automateable (including things like sample accurate filter, comp & eq changes, fx pararemeter sweeps, etc.) and VST & DX plugins are bypass automateable. It also has a "Mixer Template" feature which allows you to save snapshots of your entire virtual consoles routing and setups, along with the usual ability to save and load all plugin presets.
SAW's engine is written in assembly which allows it to be a lot more efficient than most other DAW apps, and it is incredibly rock solid stable. This combined with what to me is superior sounding internal processing math (all multiples and divides are done using 64bit integer math, all processes return a full 32bit DWORD result - and not just 24bits of data in a 32bit container that you get with most DAW's - before passing it on to the next process) and a wide variety of native effects plugins that process with 64bit math and sound to my ear much much better than what you would expect from a plugin makes it a superior choice to a lot of the other better known mastering applications. It can use all VST & DX plugins and the UAD-1 plugins operate with no added latency in it also.
I often use this "Live" mode when doing vinyl mastering - where for work flow reasons usually all processing is done on load out. Another use for it is when doing CD mastering as it lets you hear the sum total of the analog processing chain along with any processing done in the DAW (which for me is where I do my brickwall limiting - usually using the SAW native Levelizer which is amazingly transparent when the threshold is set at what I consider "reasonable" levels - and occasionally with the Waves L3). This is important as things like digital limiting will often influence choices like what eq you wish to apply in the analog realm. This also lets me do a hybrid work flow where I do all analog processing on load in - and while I was able to hear all the digital processing at the same time as I am tweaking the analog process chain I can still have the option of second guessing myself regarding the settings of the digital processing (or apply additional changes per phrase or song section or even single note if I wish) as I don't have to commit to it until load out.